Psychology 2220A/B Lecture Notes - Lecture 8: Dopaminergic, Substantia Nigra, Agonist

• School: Western University
• Department: Psychology
• Course: Psychology 2220A/B
• Professor: Jody Culham

Document Summary

1: metabotropic: g protein released when nt binds to receptor and diffuses to other parts & Ionotropic: ligand-gated ion channel leads to opening of channels. More common than ionotropric receptors but more complicated. Mechanisms for epigenetic changes to dna expression: electrical: aka gap junctions ap can jump across synapse w/out chemical transmission. Used when signals need to be fast. Neuron use: affect other neurons psps & second messengers. Drug actions: can act at any stage of synaptic transmission. Agonists; drug that increase effectiveness of synaptic t. Antagonists; drugs that decrease the effectiveness of s. t. Excitatory nt: causes depolarization (epsps) in post synaptic neuron more likely to. Most nt glutamate most common excitatory nt. Inhibitory nt: causes hyper polarization in post-synaptic neuron less likely to re. If nt = excitatory > increased epsps post-synaptic neuron > likely to re. If nt = inhibitory > increased ipsps post-synaptic neuron < likely to re.