BI110 Lecture Notes - Lecture 23: Nuclear Membrane, Signal Transduction, Chromosome

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3 Feb 2017
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Cell cycle is controlled by complexes of cyclin"s together with cyclin-dependent protein kinases(cdks) Cdk"s: only activated when combined with a cyclin, add phosphate groups to target proteins when activated by a cyclin. Different cyclin:cdk combinations regulate cell cycle transitions at different checkpoints Progression through the cell cycle is controlled by checkpoints. Cells that do not divide do not pass the g1 checkpoint and remain in g0. Once a cell passes the g1 checkpoint, it is usually committed to complete mitosis. Cells with dna or chromosome damage will fail to pass the g2 or m checkpoint. M checkpoint not passes until spindle attached to kinetochores. Class of proteins whose concentration depends on the cell cycle phase. Cyclin"s bind to and activate cyclin-dependant kinases(cdk"s), which phosphorylate other proteins involved in cell cycle. Maturation(or mitosis)-promoting factor (mpf) is a cyclin-cdk"s complex that participates in enzyme activation, nuclear envelope breakdown, and chromosome condensation.

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