BI110 Lecture Notes - Lecture 19: Phosphodiesterase, Adrenal Gland, Sildenafil
Document Summary
Phosphorylaion frequently changes a proteins conformaion and surface charge. 3-) afect electrostaic atracion and repulsion within a protein, changing its shape. Changes in electrostaic interacions may also afect the protein"s surface, potenially afecing how it interacts with other molecules. Purple is posiive electrostaic potenial; yellow is negaive potenial. Phosphatases are an important component of phosphorylaion cascades. Phosphatase is there in low abundance: always present, always acive (background level of acivity) Every ime a phosphatase dephosphorylate one of its target, its able to phosphorilate again and reacivated. Add a signal molecule, turn on the response, but no phosphatase is present, wouldn"t be able to turn of. Difuse through cell, bind to protein and acivate protein. Many kinds of second messengers: ex. cgmp (2nd messenger involved in smooth muscle relaxaion blood vessel dilaion drug developed that blocked the conversion of cgmp to gmp. Simulaion of glycogen breakdown in liver cells by epinephrine.
