BI110 Lecture Notes - Lecture 9: Peptide Nucleic Acid, Thioester, Ribosomal Rna

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29 Apr 2016
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Ribozymes are rna molecules that catalyze specific reactions. Dna and proteins may have evolved after rna. Rna can serve more than just as an intermediate between dna and protein. Rna can also do what proteins do (multifunctional molecule) Rna would have had to have been able to replicate itself or other rna molecules. The ability to convert rna sequence into an amino acid sequence of proteins. Once this occurs, these organisms have a huge evolutionary advantage. Proteins are more diverse than rna therefore the number and type of proteins that can be formed are much more than rna. Protein-catalyzed reactions are more efficient than rna-catalyzed reactions. Ribosomes are made up of proteins and ribosomal rna (rrna) rrna is the catalytic part of the ribosome. In vitro evolution approach: huge set of rna molecules in different sequences of nucleotides. Tried to select randomly mutated sequence and repeated in the last 18 times.

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