BI226 Lecture Notes - Lecture 6: Microsatellite, Caat Box, Tata Box
Document Summary
Interspersed: sines (short interspersed elements) and lines (long interspersed. Re(cid:448)ie(cid:449): 5" capping and poly-a tail addition elements) Picking and choosing which exons go into mrna. Clicker question: question on test and problem set. Chromatin dynamics: euk"s dna is (cid:449)(cid:396)appe(cid:396) a(cid:396)ou(cid:374)d histones and other chromosomes proteins, if tightly coiled rna polymerase is blocked, low levels of transcription. silenced, deacetylated state, chromatin remodeling proteins can acetylate histones causing conformation to relax. Dna base modification: methylation of dna associated with transcriptional changes, especially with cytosine followed by guanine (cpgsites, clusters of dna with 5-methylcytosine-p-guanine sites is associated (cid:449)ith t(cid:396)a(cid:374)s(cid:272)(cid:396)iptio(cid:374)al i(cid:374)a(cid:272)ti(cid:448)e dna sile(cid:374)(cid:272)ed. Epigenetics: definition: (cid:862)a(cid:374)y he(cid:396)ita(cid:271)le change in phenotype that is not associated with (cid:272)ha(cid:396)ge i(cid:374) the se(cid:395)ue(cid:374)(cid:272)e of dna(cid:863, some mechanisms might include, chromatin protein methylation, phosphorylation, acetylation, particular gene given to offspring depends where it comes from. **methylation and imprinting depends who you inherit it from deletion of chromosome 15. Stress that was present in history: ** very controversial.
