BI470 Lecture Notes - Lecture 1: Nuclear Membrane, Phosphatidylserine, Iridoviridae
21 Nov 2016
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A subcellular (cid:494)organism(cid:495) with a parasitic life cycle. Infection may be lytic: causing cell death (rare) Can be oncogenic: cancer-causing; cancer cells constantly replicate and the virus wants to constantly replicate. Not true for viruses: energy production, respiration, response to negative environments, locomotion, growth, ability to replicate, evolve, contain nucleic acids. Prions: the line gets grey and fuzzy. 1392: used to define a venomous substance, a poisonous substance secreted by animals. 1728: used to define an infectious agent. 1789 and 1885: vaccine development for smallpox (edward jenner) and rabies (louis. Effective but had no idea how they worked or what kind of pathogen they were combating. 1892: filter-passing substance chemical or infectious, infectious protein/nucleic acid complex. Visualization of viruses didn(cid:495)t occur until (cid:883)9(cid:885)(cid:882)s with the advent of electron microscopy: 1674 protozoans, 1676 bacteria. Even after we could see them, scientists still thought that viruses were chemical toxins.
