CH250 Lecture Notes - Lecture 34: Silent Mutation, Missense Mutation, Bioinformatics
Document Summary
Silent: 1 base pair changed, still codes for same codon. Nonsense: 1 aa changed, creating a stop codon. Figure 4. 24 dna bioinformatics can be used to predict amino acid mutations that could alter protein structure and function. Single nucleotide mutations in the dna can cause missense, nonsense, or frameshift mutations that change the amino acid sequence of the protein. Silent mutations change the dna sequence without altering the amino acid sequence, owing to redundancy in the genetic code. Conformational variations of a key enzyme offer clues to cancer drug resistance. Some proteins, such as the iron binding protein lactoferrin, undergo large conformational changes in response to ligand binding (protein domain colored in red). On pdb files 1lfg (open) and 1lfh (closed). Figure 4. 26 the arrangement of amino acid side chains along the polypeptide chain directly affects the surface chemistry and ligand binding properties of proteins. a.
