CH250 Lecture Notes - Lecture 59: Hmg-Coa Reductase, Atorvastatin, Statin
Document Summary
Dietary modifications and statin drugs are commonly used to reduce serum cholesterol. Statin drugs target the enzyme hmg-coa reductase, which is an enzyme in the cholesterol biosynthetic pathway. Here, the statin drug atorvastatin is shown bound to the active site of. Credits: athletic woman: alin dragulin/alamy; fried egg: miguel garcia. Atorvastatin: based on pdb file 1hwk; white pills: greg wright/alamy. Figure 7. 3 an example of the induced-fit model of enzyme catalysis is the glycolytic enzyme hexokinase, which undergoes a large conformational change upon binding of the glucose substrate. The location of the glucose molecule shown in the free (unbound) form of hexokinase is arbitrary, as glucose was not present in the protein crystal. Proteolytic cleavage: taking a protein and cutting it with an enzyme. Figure 7. 61 the catalytic asp residues in the pepsin active site are located at the bottom of a large cleft that is accessible after the n-terminal fragment of pepsinogen is removed by autocleavage.
