CH250 Lecture Notes - Lecture 53: Partial Pressure, Hemoglobin, Enzyme
Document Summary
Increase in altitude partial pressure of oxygen in atmosphere drops. In altitude for long period of time = body will adjust. Changes in bpg levels inside arythrocytes are the cause of oxygen binding changes at varying altitudes. @ sea level = kpa o2 = 13. Bpg conc. increases at higher altitude bpg is a negative regulator of o2 binding more bpg = less o2 binding. Lower @ high altwould think heme would bind more o2 not true! Figure 6. 28 changes in 2,3-bpg affect oxygen binding to hemoglobin. The oxygen saturation ( ) of hemoglobin shifts in response to 2,3-bpg concentration. At high altitudes, humans make more 2,3-bpg, which results in increased o2 unloading in the tissues, as evidenced by the greater difference in fractional saturation at increased 2,3-bpg levels. Tissues produce co2 (by oxidizing fuel molecules); high conc. 2 ways o2 gets transported from lungs to tissues: Dissolves in blood plasma (co2 more soluble than o2 in liquids)
