KP222 Lecture Notes - Lecture 10: Incubation Period, Myoglobin, Myofibril
Lecture 10:
Muscles need ATP
1. Substrate level phosphorylation of ADP by creatine phosphate
2. Anaerobic glycolysis
3. Oxidative phosphorylation of ADP in mitochondria
Role of ATP in the cross-bridge
- Unbinds myosin (rigor)
Hydrolysis of ATP
- Moved myosin to high energy stated (cocked positon) and ready for the power stroke
Pump Ca2+ into SR disengage A + M hydrolysis of ATP put myosin head into high
energy position
Substrate phosphorylation
- Borrow phosphate group (Creatine)
- Add Creatine to make ATP
- Anaerobic glycolysis: low oxygen levels,
- Aerobic metabolism: generating ATP in muscle
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Document Summary
Muscles need atp: substrate level phosphorylation of adp by creatine phosphate, anaerobic glycolysis, oxidative phosphorylation of adp in mitochondria. Moved myosin to high energy stated (cocked positon) and ready for the power stroke. Pump ca2+ into sr disengage a + m hydrolysis of atp put myosin head into high energy position. Soleus: does not produce force quickly but it does for a long time so it would be red. Myoglobin: carries oxygen but only found in muscle (muscle oxygen) Higher capillaries to bring the oxygen to the muscle. Slower contraction speed: dependent on the myosin atp activity. Recruit them when you need a powerful contraction. Generate more force because they have larger fiber diameter and motor unit size (high innervation ratio) Fast myosin (type iix produce force more quickly) Not resistant to fatigue have a low oxidative capacity. Good at glycolysis can produce atp very quickly. Early stages: use creatine because takes type for glycolysis to phosphate.
