PS267 Lecture Notes - Lecture 5: Local Field Potential, Functional Neuroimaging, Block Design
Document Summary
During active states there is an increase in oxygenated blood in venous system. Paramagnetic = can"t technically act like a magnet, but a magnet can affect it. In 1990 ogawa and colleagues demonstrated that hemoglobin could act as a naturally occurring contrast agent in mri. Changes in concentration of oxyhemoglobin could be used as a measure of changes in local neural activity bold blood oxygenated level. Cognitive neuroscience exploded in 1990 because of fmri. fmri advantages. Has the greatest spatial resolution of all current non-invasive functional neuroimaging techniques. If you want to look on things on microcellular side. Deep brain structures can be imaged unlike meg and evoked potentials. Anatomical-functional registration problems are minimal unlike evoked potentials, Take mri and fmri at same time at same spots all the time, don"t need to co-register different areas. Compared to pet it is relatively non-invasive no radioactive tracers are used many experiments on same subject are possible.
