PS267 Lecture Notes - Lecture 14: Transient Global Amnesia, Anterograde Amnesia, Neurofibrillary Tangle
Document Summary
Lecture 14 memory part 2: the anatomy of memory, memory deficits: amnesia, mechanisms of memory, the medial temporal lobe memory system, memory consolidation, cellular basis of learning and memory. Medial temporal lobe memory system: evidence from amnesia: People with medial temporal lobe lesions are unable to acquire new declarative memories: area includes: amygdala, hippocampus, and surrounding parahippocampal, entorhinal, and perirhinal cortical areas, remember emotional things better than normal boring things thanks to amygdala. H. m. hippocampal lesions not as extensive as originally believed: entire posterior hippocampus in tact! Specific lesion restricted to the ca1 pyramidal cells of hippocampus: severe anterograde amnesia (like hm) Further evidence for the role of the hippocampus in forming long-term memories: transient global amnesia. Blood supply to medial temporal lobe temporarily cut off = sudden state of anterograde amnesia. Normal performance on all tests but long: patients with lesions to brain areas connected to medial term/declarative memory tests temporal lobes, patients with alzheimer"s disease.
