PS268 Lecture Notes - Lecture 8: Immunotherapy, Sexual Dysfunction, Insomnia
Document Summary
Over the counter drugs & dietary supplements (herbal. *blocks cyclo-oxygenase, which produces prostaglandins- prostaglandins cause pain, inflammation, and fever. *inhibits alcohol dehydrogenase activity-makes you get drunk faster. Prostaglandins trigger clotting; cyclo-oxygenase (cox) has two isoforms- isoform 1 (cox1) is important for maintaining the gastric lining of the stomach and blood clotting (cox2 is the inflammatory and pyretic enzyme) Potential of reye"s syndrome in children (aspirin + flue/ chicken pox; leads to lethargy, vomiting, coma, etc and death in kids) *may act via cannabinoid system (inhibits anandamide reuptake, thereby indirectly activating the cannabinoid receptors) *discussions about making tylenol a hidden under-the-counter medicine that you have to ask for in the pharmacy. Blocks prostaglandin biosynthesis; more selective for cox2 (anti-pyretic, anti- inflammatory) than cox1 (anti-clotting, anti-gi system) ,000 in pain meds per year sold just for wlu students. *you get greater pain relief from combining two different pain killer drugs than taking two of the same kind.
