ADMS 3502 Lecture Notes - Lecture 53: Ankylosing Spondylitis, Serum Protein Electrophoresis, Pathologic Fracture

• School: York University
• Department: Administrative Studies
• Course: ADMS 3502
• Professor: Cristobal Sanchez- Rodriguez

Document Summary

Is skeletal disorder characterized by reduced quantity and quality of bone risk of fracture. Bone is a dynamic organ but pathogenesis results when bone formation < bone resorption. Diagnostic categories: < 1sd is normal, btw 1 and 2. 5 sd is osteopenia, and >2. 5 sd is porosis. Fragility fracture for severe osteoporosis of wrist (16%), hip (18%), and compression vertebral (16%), and other like proximal humerus fracture = 1/5 chance and costs billion in states. Risk factors: female, elderly, menopause, smoking, alcohol, sedentary life style, thin body type, hereditary, caucasian race, and steroid use. Pathogenesis decreased synthesis of insulin-like growth factor (igf i) or igf ii as aging & menopause leads to general decline of igf i and steroids inhibit igf i synthesis. Investigation for osteoporosis: x-ray, bone densitometry, and look for secondary causes by serum ca, alp, p and creatinine, serum protein electrophoresis, liver enzymes, tsh, testosterone.