ADMS 3502 Lecture Notes - Lecture 51: Coagulopathy, Hepatic Veins, Nonsteroidal Anti-Inflammatory Drug
21 May 2020
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Document Summary
Various nsaids, liver damage from certian nsaids are more common yet all these drugs remained on the market but again cases/100 000 is low. Overdose of acetaminophen accounted for close to 50% associated with fulminant hepatic failure which has a high mortality rate. Hypersensitivity type either drug itself or reactive metabolite binds to liver cell proteins producing adducts that becomes autoantigen and immune system attacks liver. Estrogens + anabolic steroids linked to certain type of liver tumors. Acetaminophen toxicity is dose related, antiarhythmic drug=amiodarone create a dose related type of fatty liver potential toxicity of oral contraceptives is long term after years of use and is linked to hepatic adenomas. Depending on drug and pathology, may be dose related acutely, or dose related accumulately, in other settings often not dose related may be due to toxic intermediate of the drug and overactive immune system in patient.
