BIOL 1000 Lecture Notes - Lecture 10: Dna Replication, Complementary Dna, Helicase
16 May 2016
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Document Summary
Increasing size, developmental complexity and diversity of functioning of multicellular eukaryotic organisms require strict control of cell division. Ultimately results in a mature body composed of different subpopulations of cells. Cell cycle is a period of growth followed by nuclear division and cytokinesis. Daughter cells are identical copies of the parent cells. In dna, the sugar-phosphate backbone is on the outside. Watson and crick hypothesized a semiconservative model for dna replication. Bacteria dna replicates in less than an hour. Dna replication involves over a dozen different enzymes. Dna replication begins at the origin of replication. Specific nucleotide sequence is where replication process begins. Dna strands unwind and separate to form a replication bubble. Multiple origins of replication and replication in both directions permits faster replication. Helicase are enzymes that unwind and separate the dna strands at the replication. Single-strand binding proteins are proteins that stabilize separated strands. Topoisomerase relieve twisting pressure on still wounded dna ahead of the replication.
