BIOL 1000 Lecture Notes - Lecture 2: Archaea, Antibody, Peptidoglycan
31 Jan 2013
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Document Summary
Calanolide a: derived from the bintangor tree, non-nucleoside reverse transcriptase inhibitor (nnrti) No effect vs. cancer cells but success vs. hiv (virus that attacks the human immune system [t-cells]) Many anti-viral and anti-cancer drugs involve the inhibition of nucleotide synthesis (blocks dna from replicating: this is usually done by blocking the action of specific enzymes. With reverse transcriptase: dna rna dna: many viruses have an rna genome (rna genome carries all of the rna plus reverse transcriptase) When it is all injected, copy dna (cdna) is produced in the host"s cytoplasm. These viruses are called retroviruses because they go backwards and create. But virus uses mainly host enzymes so they are difficult to kill. Rna transcriptase is usually what the scientists want to destroy. Most reverse transcriptase inhibitors are nucleoside derivatives (analogs) Bind to an enzyme involved in the synthesis of the cdna and that includes nucleotide synthesis and blocks it"s action. Nucleoside analogs can affect post-cell enzymes side effects.
