BIOL 2020 Lecture Notes - Lecture 18: Furosemide, Spironolactone, Hydrochlorothiazide
8 May 2020
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Diuretics and where they work: diuretics, diuretics drug that antagonizes renal tubules preventing na absorption, see slide , three examples, furosemide- acts in ascending limb reabsorbs na, k and cl. Furosemide looks like chloride and binds to transporter and inhibits its function: hydrochlorothiazide- binds to cl transporter site and inhibits its function. In the loop of henle desalination plant that reabsorbs nacl leaving water behind so you end up with very dilute fluid. Lots of adh leads to lots of concentrated urine. So, to summarize, when adh is present, urine volume tends to be small and concentration tends to be high. Free water (without salt: increased intake can contribute but rarely the sole cause. Adh around when it should have been inhibited by excess water: why would you have adh acting when it should have been inhibited, some people with certain kinds of lung cancer that makes adh. You dilute the fluids and swell the tissues.
