BIOL 2020 Lecture Notes - Lecture 4: Conjugate Acid, Linus Pauling, Acid Dissociation Constant
29 Apr 2016
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*hydroxyl group can be deprotenated but only for. Isoelectric point is the ph at which a molecule (amino acid or peptide) has no net charge. For amino acids with two ionizable groups (nh3, cooh) The carboxyl group of one amino acid joins the amine group of another in a condensation reaction. Linus pauling was the rst to characterize the peptide bond as rigid and at (no free rotation about peptide bond) Found that c-n bonds between two amino acids are shorter than other c-n bonds. Gives them partial double-bond characteristics (they are resonance hybrids) Regardless of size, peptides have two distinct ends: Amino acids that have formed peptides are called amino acid residues. Residues are what used to be amino acids, but now form a peptide. Always start at the n-terminus and go to the c-terminus. Depending on the speci c case, each of these can be considered a protein. Simple proteins: made up only of amino acids.
