BIOL 2021 Lecture Notes - Lecture 21: Mitogen, P53, Growth Factor
30 Mar 2017
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When they are leaving more progeny, they have a larger population in the next generation this means that more random mutations are possible, meaning faster evolution. Mutation that prevents it from hydrolyzing the gtp to gdp, making it hyperactive. Mutated in 30% of human cancers fig 15-55 parallel pathways ras map kinas division ras pi3 kinase growth: 2) epidermal growth factor is a mitogen that allows cell cycle entry at g1. Egf receptor mutation would make it overactive, so the signalling is overactive. This leads to survival and growth and proliferation. Fig 20-19: 3) myc fig 17-61 mitogen cell cycle entry. Rb and myc: 2) pi3-kinase/ mtor pathway that leads to growth fig 17-64 growth factors that activate rtk which activates pi3 kinase with activate. Tor with activate protein synthesis fig 15-55 ras pi3 kinase fig 20-26b glucose uptake. Environmental factors: about 80-90% of cancers are avoidable fig 20-37, 50% can be prevented by simple lifestyle changes.
