BIOL 2021 Lecture Notes - Lecture 12: Tumor Suppressor Gene, Chromosome Segregation, Macromedia Homesite
Document Summary
Biol 2021- cell biology: chapter 20: cancer: one in 3 canadians will get cancer, 1/5 will die of cancer. 20-3: two heritable properties that make cells cancerous: reproduce without normal restraints on growth and division, invade and colonize new territory. 2 stages of tumor: benign = not invasive. Tumor= neoplasm uncontrolled growth: malignant = cancerous = invasive. Metastases = seco(cid:374)dary tu(cid:373)or other sites, pri(cid:373)ary tu(cid:373)or is usually re(cid:373)oved, it"s the secondary tumor that usually kills the person: cancer as a mircoevolutionary process, cancer= genetic disease, individual mutant clone of cells. Evolution: population with heritable variation, selection for individuals with advantage = leaving more progeny. Clonal evolution of cancer: all cells i(cid:374) a patie(cid:374)ts" tu(cid:373)or have sa(cid:373)e (cid:373)utatio(cid:374). 20-6: colon cancer vs age: cancer us a disease of old age, cancers show tumor progression. 20-8: cancer evolve with time from mild disorder to full-blown cancer.
