BIOL 2021 Lecture Notes - Lecture 15: Triosephosphate Isomerase, Pyruvate Dehydrogenase, Dihydroxyacetone Phosphate

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9 Jul 2017
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Energy stored in sugars (carbohydrates) released to perform biological work. Glucose enters the cell via a specific transporter protein. Uses: glucose, atp, adp + pi, nad+ (necessary co-factor) Produces: pyruvate, atp, nadh can be further oxidized under aerobic conditions to make atp. Aerobic conditions: conversion to acetyl coa (pyruvate dehydrogenase) for use in tca cycle and oxidative phosphorylation for atp production. Anaerobic conditions: lactate (animal muscles, ethanol (yeast) Glucose + 2 adp + 2 nad+ + 2 pi. 2 pyruvate + 2 atp + 2 nadh + 2 h+ + 2 h2o. 10 step process some steps tightly regulated. Each glucose (6 carbons) split into two pyruvates (3 carbons each) Two molecules of nad+ are reduced to nadh. Investment phase: first 5 reactions, glucose is activated by phosphorylation, priming reactions need to invest energy to get more out, uses 2 atp"s per glucose, glucose is converted to two molecules of glyceraldehyde 3-phosphate (g3p)

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