BIOL 2021 Lecture Notes - Lecture 17: Spindle Apparatus, Nuclear Membrane, Origin Recognition Complex
12 May 2013
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Cdks activated by binding cyclin dependant kinases. Cdks that are dependent: g1 cdks. Control activity of g1/s cdks: g1/s cdks. High in late g1, fall in s-phase. Trigger commitment to cell cycle entry (start: s-cdks. S = synthesis stimulate chromosome duplication. Wee1 kinase inhibits cdks inhibitory phosphate by putting an inhibitory phosphate. If wee1 not made, lots of division but no growth! Cdc25 phosphate removes inhibitory phosphate, activates cdks: most important for m-cdk control at mitosis. Bind to cdks, inactivation important for g1/s caks and s cdks. Ubiquitin ligase transfers ubiquitin to protein and marks it for destruction. Apc activated by cdc 20 in anaphace. Apc activated by cdh1 in late mitosis early g1. Scf = ubiquitin ligase fig 17-20a: targets: cki proteins in late g1, activates s-cdk dna replication. Changes in cyclin gene expression in some cells: mostly in g1/s and s cyclins. S phase copy all dna once and only once. Dna synthesis initiation at origin elongation.
