BIOL 2021 Lecture Notes - Lecture 8: Vesicle Fusion, Lipid Bilayer Fusion, Membrane Protein
9 Feb 2018
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This chapter = green pathways = vesicular transport. Fig 13-3a, roadmap of vesicular traffic: biosynthetic-secretory pathways (red arrows), new prot, carbs made and delivered to pm, secreted outside the cell. Er to golgi, to extracellular space: new proteins, carbs, lipids delivered to pm or extracellular space, endocytosis (green arrows, pm removed and delivered to endosomes. Things taken into the cell: retrieval pathways (blue arrows). Fig 13-3b, vesicular transport compartments: transport vesicles = membrane enclosed containers travel between compartments. The lumen of each membrane-enclosed compartment is topologically equivalent to the outside of the cell: cargo = what is carried by the vesicles, lumen of vesicles is topologically equivalent, video 13. 2 biosynthetic-secretory pathway. Newly formed proteins that are going through er and going to be going to golgi and then secreted. Question: vesicle budding from the donor compartment and vesicle fusion with the target compartment require membrane fusion events. No. budding requires fusion on the lumen site.
