BIOL 2021 Lecture Notes - Lecture 13: Ras Superfamily, Cytoskeleton

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13 May 2018

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• Ras proteins (854-855)

o Activated by RTKs.

o Use adaptor proteins.

o Monomeric GTPases.

• Fig 15-8: monomeric GTPases

o Molecular switch.

o activate = GTP bound.

o Inactivate = GDP bound.

o GEF activates, GAP inactivates.

• Table 15-5 RAS superfamily

o Similar structures and mechanisms.

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