BIOL 2040 Lecture Notes - Lecture 4: Chromatin Remodeling, Tandem Repeat, Consensus Sequence
16 Oct 2017
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99. 9 genetic similarity to everyone else highly repetive dna localized to centromeric and telomeric groups middle repetitive. In vntrs and strs number of tandem copies varies bw individuas at specific locations throughout gene. Make good genetic markers bc variable nature (number of repeats) Primers match segment of dna you want to copy; required bc dna poly cant just attach anywhere. Gel electrophoresis smaller size go through faster. Dna associated with proteins that help pack it into a smaller space. Compacted chromatin throughout cell cycle including cell division (looks like this for most of cell cycle) Condensation only during m phase different chromosomes have different chromosome banding patterns. Utr"s i(cid:373)po(cid:396)ta(cid:374)t fo(cid:396) sta(cid:271)ilit(cid:455) a(cid:374)d t(cid:396)a(cid:374)slatio(cid:374) of (cid:373)rna. Heteroduplex - take dna denature it and bind mrna for that gene to the template strand bc complementary to it. Consensus sequence in exons and introns indicate where splicing should occur.
