BIOL 2040 Lecture Notes - Lecture 25: Duchenne De Boulogne, Muscular Dystrophy, Neurology
Document Summary
Duchenne muscular dystrophy (dmd) was first documented in italy in 1834 by giovanni. However, dmd takes its name after guillaume duchenne, a neurologist from france who provided a detailed description of the disease in his book paraplegie hypertrophique de l"enfance de cause cerebrale in 1861. In 1868 he presented an additional 13 other cases, and was also the first to extract living tissue from an affected individual for examination and research purposes. Dmd is a recessive x-linked disorder, which consequently predisposes males to higher chances of inheritance. It is the most common form of the muscular dystrophies, and also the most severe. Muscle degeneration and muscle weakness, occurring in a proximal to distal direction, are the primary symptoms of dmd, which lead to other physical symptoms such as enlargement of the calves. Symptoms are observed as early as the age of three.
