BIOL 2060 Lecture Notes - Lecture 26: Renal Blood Flow, Amine, Inulin

• School: York University
• Department: Biology
• Course: BIOL 2060
• Professor: Hernan Humana

Document Summary

Bilirubin: bilirubin is breakdown product of hemoglobin, rbcs (cid:271)e(cid:272)o(cid:373)e old or da(cid:373)aged, the(cid:455)"re (cid:271)roke(cid:374) do(cid:449)(cid:374) (cid:271)(cid:455) (cid:373)a(cid:272)rophages i(cid:374) splee(cid:374) & li(cid:448)er, remaining non-iron heme group converted to green pigment biliverdin which is reduced. If found in blood, then chance of being found in urine: no detectable bilirubin in urine normally. Abnormal increase in conjugated bilirubin in blood (hyperbilirubinemia) results in being excreted in urine. Presence of bilirubin in urine referred to bilirubinuria: hyperbilr & with same disorders of urobilinogen. Urobilinogen test conjugated with bilirubin levels: biliary obstruction due to presence of gallstones- impair secretion of bilirubin to si. Most bil secreted into blood & filtered out by kidney. Bile duct obstruction leads to increase in bilr urinary level, while urobi in urine remain same- absent: hemolytic anemia produces: elevated uro levels, no bil. Excess unconjugated bil, not soluble cannot be filtered & not in urine: liver disease (hepatitis, cirrhosis), urinary levels for uro & bil are increased.