BIOL 2060 Lecture Notes - Lecture 32: Straight Arterioles Of Kidney, Osmoreceptor, Posterior Pituitary

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Trans epithelial transport: lumen-> epithelial -> interstitial fluid -> capillaries. Na+ reabsorption: passive movement by channel into tubular by electrochemical gradient. Active movement by k+/na+ transporter in basolateral into interstitial fluid. Important for reabsorption passively of water, aa, cl, urea. 25% reabsorbed by loop to produce concentrated urine. Water reabsorb: lumen to tubular by water channels by osmosis. Water moves out tubular to interstitial where na+ high & diffuses into peritubular capillaries due to hydrostatic pressure. Glucose reabsorption: glucose moves into tubular by na+/glucose 2nd active transporter. Na+ moves passively into & glucose moves actively into tubular against gradient. Amount reabsorbed determined by tm (mg/min) & renal threshold (mg/100ml). all absorbed until tm reached. When renal threshold reached, transported saturated & no more absorbed. Osmolarity of fluid decreases at top of ascending. Descending fluid isotonic w/interstitial; ascending fluid is hypotonic with interstitial, but importable. Vasa recta- flow counter current with tubular flow.

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