BIOL 3051 Lecture Notes - Lecture 5: Esophagitis, Magnesium Hydroxide, Esophageal Cancer
20 Apr 2020
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Introduction: dyspepsia is epigastric pain lasting > 1 month. Symptoms include epigastric fullness, nausea, vomiting, heartburn, epigastric pain: gerd: frequent acid regurgitation or heartburn (burning feeling in stomach or lower chest rising up to neck). Symptoms: epigastric pain, nausea, dysphagia (difficulty swallowing), odynophagia (pain w/swallowing, erosive esophagitis upon endoscopic investigation. Dyspepsia: dyspepsia can be caused by pud, gerd, gastric or esophageal cancer, good intolerances, medications, infections. Gerd: defective lower esophageal sphincter (les) which normally prevents reflux of gastric contents into esophagus, hernia, impaired esophageal peristalsis, delayed gastric emptying, excessive gastric acid production, bile reflux, gerd may result in structural damage to esophagus. Gerd triggers & exacerbating factors: disease state: asthma, pregnancy, stress, drugs (reduce lower esophageal sphincter pressure): alpha blockers, anticholinergic, benzodiazepines, beta agonist, calcium channel blockers, nicotine, opioids, theophylline. Lifestyle: obesity, smoking, diet (fatty food, chocolate, coffee, alcohol) reduce les tone. Goals of therapy: reduce or eliminate symptoms, reduce or prevent recurrence of symptoms, prevent complications.
