BIOL 3070 Lecture Notes - Lecture 18: Intelligence Quotient, Tumor Suppressor Gene, Polonium Dioxide
Document Summary
Increase tissue osmolarity (introduce new solutes like glycogen broken down into glucose used during flight this increases osmolarity in surrounding tissue so water drawn from tips) Hifs: hif-1: consitituvely expressed in all cells, hif-2: tissue-specific expression. Proposed mechanism by which these hifs are thought to operate. Hif-2 thought to operate in similar fashion (not as much known about. Under normal o2 conditions, hif-1 continuously synth/degraded. Diff. isoforms of these enzymes that perform similar functions (oxygen- Under normoxia, phds hydroxylate hif-1 alpha groups (allows it to bind detectors in the cell) and interact with vhl) Hif-1 alpha-vhl complex recruits ubiquitin (involved in diredcting proteins to specific cellular compartments it"s in all euk. cells) this protein then marked for degradation to proteasome (intracellular complex of proteins involved in degradation of damaged/unneeded proteins) Hif-1 alpha then degraded and ub. recycle for future use (not needed anymore)
