BIOL 3120 Lecture Notes - Lecture 2: Pattern Recognition Receptor, Innate Immune System, Adaptive Immune System

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9 Feb 2017
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Signals: generated by binding of ligand to receptor noncovalently. Signals can be modified by amount of receptor or ligand. Often requires multitudes of signals and receptors. More receptors the cells have, the greater events. One receptor can have multiple binding sites for signals = avinity. One binding site = weak two = increased avinity, stronger signal since it picks up more ligands e. g. b cells often require 2 antigens to bind for enough signals for activation. Pathogens have multiple antigens and antigens have multiple epitopes. Pathogens = anything that can make you ill. Antigens = a part of pathogens that adaptive system can bind to. Epitopes = a small tip of antigen where antibodies can bind. Clonal selection = b cells recognizing unique epitopes. Epitopes on one antigen can be same or different. Antigenesity = pathogens with different # of antigens. More antigenic = more antigens easier to clear. Applies for adaptive system only (b and t cells)

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