BIOL 3120 Lecture Notes - Lecture 3: Repressor, Nfat, Chemotaxis
Document Summary
Video 3: cell signaling and cytokines: cell signaling is very complicated; cells respond to more than one signal at a time, receptor is joined with an adapter protein (dogging protien) If you have different receptors for the adapter protein, they tend to have a redundant signalling. Its presnet in teh cytoplans by repressor called i-kb (inhibitor: when i-kb is phosphorylated, ikb is destroyed, it no longer bind with nf-kb and nf-kb enter the nucleus and change transcriptional levels. It is activated through diff pathways such as map kinase cascade: nfat, not seen as often, not significant. Cytokines: most cytokines act in autocrine or paracrine (form of cell signalling, some can participate in endocrine signalling (travel to other part, mainly 6 cytokines family (see the table) Interleukin (just another word for cytokines) means communication between leukocytes: all cytokines are interleukin, chemokines are part of chemoattraction, interleukin-1 family (il-1, part of the inflammatory response.
