BIOL 4010 Lecture Notes - Lecture 28: Folliculitis, Lipophilicity, Malassezia
1 Jan 2021
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The ranking in terms of effectiveness from most to least effective is as follows: ketoconazole & ciclopirox or moderate potency corticosteroids, hydrocortisone or calcineurin inhibitors, selenium sulfite, zinc pyrithrione, keratolytic and last is coal tar. Antifungals, ketoconazole & ciclopirox olamine, are equally efficacious in providing symptom control by decreasing the presence of lipophilic malassezia yeast. Itraconazole at daily dose of 200mg for 2 consecutive months has show better efficacy and less incidences of relapse during a 4-month period. Calcineurin inhibitors has similar efficaciously to antifungals and topical steroids in reducing symptoms of sd. Less applications of calcineurin inhibitors are required to achieve desired control. Keratolytic agents alone do not provide effective symptom control and relief. Keratolytic agents loosen scaly flakes on skin, allowing for better penetration of other topical medications for improved efficacy. Agents like salicylic acid, sulfer, coal tar, selenium sulfite and zinc pyrithione provide mild to limited relief at reducing symptoms.
