BIOL 4010 Lecture Notes - Lecture 23: Paracetamol, Halothane, Degranulation
1 Jan 2021
School
Department
Course
Professor
Document Summary
Pscalda: phenotype, size of lesions, color of lesions, arrangement of lesions, distribution (where is it located, always remember hair, nails, mucous membranes, and intertriginous areas. Caused by: aminopenicillins, anticonvulsants, tmp/smx (trimethoprim/ sulfonamides, nsaids. Infection: collagen vascular disease, graft vs host disease. Common mechanisms of drug induced rxn- predictable: toxic: overdose, normal dose (kinetic differences), accumulation (hepatic dysfunction, pharmacologic: alopecia from cytostatic. Inhibition of cell growth which could result in hair loss. Common mechs of drug induced rxn unpredictable. Idiosyncrasy or intolerance: autoimmune, allergic, type 1-3: circulating antibodies, type 4: cell-mediated (eg. contact dermatitis) Toxic vs allergic rxn: toxic rxn"s diminish/subside when drug discontinued can rechallenge, allergic rxn: persist or worsen as #ab increase don"t rechallenges. Common drug-induced skin reactions: fixed drug eruptions, acne, pigmentation reactions, exanthems (morbilliform or maculopapular) rash, urticaria- hives, erythema multiforme & steven"s johnson syndrome, toxic epidermal necrolysis (ten, hypersensitivity syndrome, petechiae and purpura, photosensitivity reactions.
