CRIM 2653 Lecture Notes - Lecture 3: Aciclovir, Finger Cot, Fosphenytoin
6 May 2020
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Mtm lab 3 - zovirax: name, strength and dosage form of medication. Cream 50 mg acyclovir/g of cream (i. e. 5% w/w). Apply liberally: indication, instructions, side effects, management and monitoring. Used for the treatment of initial episodes of genital herpes simplex infections (i. e. cold sores). Therapy should begin as early as possible after start of infection. Acyclovir is highly specific for herpes simplex specified thymidine kinase. It gets phosphorylated to acyclovir diphosphate and triphosphate. Acyclovir triphosphate is both an inhibitor of, and a substrate for, herpesvirus-specified dna polymerase. This blocks viral dna synthesis, and suppresses the virus. In summary, it blocks formation of new viruses, which can suppress the infection. It is a synthetic acyclic guanosine nucleoside analog. Apply liberally to the affected area 4 to 6 times daily for 4 days and up to a maximum of 10 days. A sufficient quantity of cream should be applied to adequately cover all lesions.
