CRIM 2653 Lecture Notes - Lecture 54: Familial Adenomatous Polyposis, Aspergillus Flavus, Tumor Suppressor Gene
23 May 2020
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Document Summary
X-linked inherited cancer syndromes: x-linked lympho proliferative disorder, fragile x chromosome syndrome. Familial cancers: certain cancers are more frequent and occur at an earlier age in certain families, but there is no clearly defined pattern of genetic transmission, siblings have 2-3 fold risk, ex. breast, colon, ovarian. Environmental carcinogens: environmental factors are the most significant causes of cancer, agents causing genetic damage predisposing to cancer include, chemical carcinogens, radiation, oncogenic viruses & bacterias, chronic inflammation. Radiation as a carcinogen: uv rays and sunlight, death from melanoma is 6x more frequent in new zealand than iceland. Ionizing radiation: medical/ occupational exposure, nuclear plants accidents. Microbial carcinogens: oncogenic viruses, hpv cervical cancer, hep b & c liver cancer, epstein-barr virus lymphomas, bacterias, h. pylori stomach cancer. Inflammation as a carcinogen: variety of chronic inflammatory diseases predispose to cancer, ulcerative colitis: increased risk of colon cancer.
