KINE 3012 Lecture Notes - Lecture 15: Ras Superfamily, Radio Television Of Kosovo, Scaffold Protein
10 Feb 2018
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Document Summary
Ras proteins: relay signals from cell-surface receptors (rho has the same function used in the cytoskeleton) They are monomeric gtpases (molecular switch) that are activated by rtks and use adaptor proteins. Proteins in the ras superfamily have similar structures and mechanisms, but different targets. 30% of all human tumors have overactive ras proteins. The ligand activates rtk, the adaptor binds, and the adaptor activates a ras gef. Ras-gtp is activated and the signal is passed downstream. To turn off the signal: protein phosphatases remove phosphates off. Rtk: gap converts ras-gtp to ras-gdp and is now inactive. Scaffold protein: map kinase modules in yeast (not rtk activated) A mating factor binds to a gpcr and induces a mating response. High osmolarity causes a sensing receptor to stimulate glycerol synthesis. Although broth processes use the same map kkk, cross-talk is avoided by binding to different scaffold proteins.
