KINE 3012 Lecture Notes - Lecture 9: Circulatory System, Hemoglobin, Hyperventilation
11 Feb 2018
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In tissues: most is carried bound to deoxyhb, when o2 is unloaded from hb at tissues. When hydrogen binds to hb it promotes off loading of oxygen. Increase in co2, increase in h+ these act to encourage offloading of co2: h+ ions combine with hb hbh, as ph drops (cid:894)in(cid:272)rease h+(cid:895), o(cid:454)(cid:455)gen doesn"t want to (cid:271)ind to h(cid:271) Hydrogen & co2 shift hemoglobin curve to right: build up of acidity drops ph; most enzymes in body work optimally at 7. 2 changes activity of enzymes-not good. Ph is lower in tissues than in lungs (less hydrogen b/c less co2) At lungs: where o2 is loaded onto hb- b/c high pressure, h+ is released from hb & combines with hco3- In tissues: o2 dissociated from hb, co2 + water froms bicarbonate and h+ h+ binds to hb, all driven by co2 & o2 gradient. In tissue cells (systemic circulation: co2 produced in tissue cell. Co2 forms bicarbonate acid via carbonic anhydrase.
