KINE 3012 Lecture Notes - Lecture 15: Aortic Aneurysm, Aorta, Histology
26 Apr 2016
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Graph demonstrate increase in systolic pressure increases depending on intensity of exercise doing. Before they exercise they have different systolic pressure ranges based on age and other potential parameters. As they lift weight, regardless the sp increase the higher the weight you lift. The magnitude of the increase depend on individual. Young individuals experience less of overall increase in systolic pressure compared to older and less fit individuals. Normal systolic p (80-120 mmhg), as lift it gets to >200. Can pull skin but it"s not elastin protein that"s mutated. If have a mutation in fibrillin you lose ability to organize elastin fibers correctly. Histology of elastin fiber in nor marl individual aorta section. Black stain is elastin fibers nicely organized in rings we see. Right side is marfan with the mutation, can still see elastin in black buts its completely disorganized not nice lamellar rings. Elastin has basic monomeric properties but not organized so lacks appropriate structural properties.
