KINE 3710 Lecture Notes - Lecture 8: Fc Receptor, Fragment Crystallizable Region, Fragment Antigen-Binding

• School: York University
• Department: Kinesiology & Health Science
• Course: KINE 3710
• Professor: Tanya Da Sylva

Document Summary

Plasma cells (activated b-cells) release antibodies that have the same antigen speci city as the receptor on them: naive b cells that have not seen an antigen yet try to nd antigens in the secondary lymphoid organs. This number changes depending on which b cells die and if we get clonal expansion so we get more b-cells. This is limited by the number of b cells we have: the more diverse your repertoire is, the better your ability to survive an infection. Structure of antibodies (y-shape: 4 chains make an antibody. The green is the heavy chain because it is longer and bigger. All the chains are linked by disulphide bonds. The heavy chain is encoded by one gene, and the light chain is encoded by another gene. Antibodies have constant and variable regions: variable region is in red at the top. This is the part that binds the antigen.