KINE 3012 Lecture Notes - Lecture 28: Macula Densa, Vasoconstriction, Membrane Potential

• School: York University
• Department: Kinesiology & Health Science
• Course: KINE 3012
• Professor: M.Connor

Document Summary

Regulation of glomerular ltration: glomerular hydrostatic pressure is the main factor for modifying glomerular ltration, if it decreases you will have a lower net ltration rate and decreased gfr. Things that can vasoconstrict or vasodilate the a ront arteriole will have a direct a ect on glomerular hydrostatic pressure: these impacts are analogous with the systemic circulation with how arteriolar vasodilation and vasoconstriction impact capillary ltration. Sympathetic nerve stimulation of the a ront arteriole releasing norepinephrine would cause vasoconstriction. So the a erent and e erent arterioles have opposite a ects. The e erent arteriole isn"t really innervated by that many sympathetic nerves, but the a erent arteriole is. Does mean arterial pressure always have an e ect on glomerular ltration rate: if map goes up, then you get an increase in capillary hydrostatic pressure, leading to an increase in gfr. The kidney has 2 main regulatory mechanisms to maintain its gfr regardless of changes in map.