NATS 1670 Lecture Notes - Lecture 38: Antigen, Antibody, Mast Cell
20 Apr 2017
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Document Summary
Is a coordinated set of nonspecific defenses in response to damaged cells and bacterial proteins. When a splinter breaks the skin, it triggers a nonspecific inflammatory response in the region if the puncture. The tissue damage triggers mast cells to release histamine from their histamine granules into the surrounding tissue. Histamine diffuses into capillaries, causing them to dilate and become leaky. As plasma leaks into the tissue, the area swells. In damaged or infected tissue, activated proteins called complement proteins and other chemicals attract phagocytes to the area. The phagocytes engulf and digest dead cells and bacteria. Histamine and complement signaling cease, and phagocytes are no longer attracted to the area. Histamine secreted from mast cells increases permeability of the blood vessels during inflammation. Leads to leakage of blood plasma and cells (phagocytes) to the injured site. The main cell types seen in an inflammatory response in its initial phases. Response to chemotaxis signal from the injured site.
