NATS 1670 Lecture Notes - Oseltamivir, Hemagglutinin, Influenza A Virus Subtype H7N9
25 Mar 2014
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Document Summary
Mortality: major causes of influenza virus-associated death, bacterial pneumonia. 200,000 hospitalizations and 38,000 deaths during typical season in the usa. 90% of total deaths from influenza persons aged >65 years. The new h1n1 influenza virus from 100 patients have been tested for resistance to antiviral medications. All have been found to be sensitive to oseltamivir (tamiflu) H7n9 bird flu may be developing drug resistance. Adsorption: virus hemagglutinin on the virus particle attached to sialic acid on cell. Sialic acid is the receptor for the influenza virus. Hemagglutinin is an attachment protein: the hemagglutinin spikes bind sialic acid, the receptor for the influenza virus. Virus hemagglutinin sticks new virus particle to sialic acid on cell surface and to other virus particles. Neuraminidase destroys sialic acid allowing the virus to exit the cell surface. Oseltamivir (tamiflu) is a structural analogue of sialic acid. Tamiflu bind to neuraminidase better than sialic acid.
