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Lecture 36

NATS 1670 Lecture 36: Lecture 36

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York University
Natural Science
NATS 1670
Motti Anafi

Lecture 36 Infectious Diseases and Host Defense: Immunology: the study of our protection from and response to foreign invading organisms and altered host cells good against virus cells Cancer cells know how to escape from the immune system ,and sometimes actually it should be blamed for the initiated of cancer cells.(20 of cancer is a product of chronic inflammation cancer is initiated) viruses: in many cases, activating the immune system is the only way to fight the disease (Ex. small pox is gone because we were able to adapt our immune system to disease) many vaccines to prevent viruses, few drugs to fight them bacteria: synergism between antibiotics and the immune system (for the antibiotics to have effect, you need to have a good immune system) Balance between Infection and Immunity: Immune systems job is to recognize self from nonself and destroy abnormal molecules and cells (The Merck Manual) When we feel fine, there is a balance between infection and immunity Infection amount of pathogens Virulence is balanced with Immunity host defense mechanisms = no infections Breaking the Balance: When the amount of pathogens is increased = less balance with immunity = DISEASE Some people are born with weak immune systems (certain enzyme isnt working) = decrease in defense mechanisms Too much immunity is not good for you = when immune system is working against the wrong target (Ex. allergic reactions)(eg.pollen,chalk,etc)(One reason may because you live in a really clean environment and rarely are exposed to dust.) Autoimmune disease: when the immune system cant recognize body as itself, normally immune systems can recognize the body (immune system is turning against itself Ex. immune system attacking joints, heart, kidneys, etc.) > immune system sometimes misses the point Acute imflammation sepsis: aggressive reactions (acute inflammation quick reaction) immune system is overreacting against pathogens, so sever that the main damage is from the immune system Chronic inflammation cancer: long term inflammation (Ex. Hep. B) + Immunology is the study of our protection from response to foreign invading organisms and altered cells. Viruses: in many cases, activating the immune system is the only way to fight the disease Bacteria: synergism between antibiotics and the immune system Immunity vs. Autoimmunity Balance between Infection and Immunity Infection = amount of pathogens virulence Immunity = hose defense mechanism There is a problem if the immune system cannot work properly People with malaria
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