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Lecture 58.docx

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Natural Science
NATS 1670
Motti Anafi

Mortality • Major causes of influenza virus-associated death o Bacterial pneumonia  Toxic shock syndrome o Cardiac failure • 200,000 hospitalizations and 38,000 deaths during typical season in the USA  90% of total deaths from influenza – persons aged >65 years What are the options we have to fight the Influenza Virus? Antiviral Drugs such as Oseltamivir (Tamiflu) The new H1N1 influenza virus from 100 patients have been tested for resistance to antiviral medications. All have been found to be sensitive to Oseltamivir (Tamiflu) H7N9 Bird Flu May Be Developing Drug Resistance Influenza Virus Adsorption: Virus Hemagglutinin on the Virus Particle Attached to Sialic Acid on Cell Surface Sialic acid is the receptor for the influenza virus Hemagglutinin is an Attachment Protein • The Hemagglutinin spikes bind sialic acid, the receptor for the influenza virus. Assembly Release Virus Hemagglutinin sticks new virus particle to sialic acid on cell surface and to other virus particles Neuramini
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