PSYC 3670 Lecture Notes - Lecture 4: Substantia Nigra, Metabotropic Receptor, Otto Loewi

• School: York University
• Department: Psychology
• Course: PSYC 3670
• Professor: Kristoffer Romero

Document Summary

*know name of transmitter & name of nucleus in which it is projected. Exogenous substance: substances from outside the body (drugs) Endogenous substance: substance from inside the body (neurotransmitter) Exocytosis: release of substance (transmitter) into extracellular space (cleft) Receptors: picky about the substances they will respond to. Ionotropic receptors: (ligand-gated ion channel) agonist binds = ion channel opens = allows ions to pass through (epsp/ipsp; usually excitatory) Metabotropic receptor: agonist binds = second messenger (g protein; alpha, beta, gamma) cause changes in cell (can alter gene expression/open nearby ion channels) but receptor itself doest contain ion channels. ^ same agonist/transmitter can bind to both ionotropic & metabotropic receptors triggering di erent responses. 1. synthesis: proteins from dna, made in cell body. 2. storage: stored in phospholipid bilayer vesicles that are walked down to terminals. 3. release: ca2+ increase in terminals = vesicles bind to membrane & rupture. Calmodulin: protein that binds calcium - important molecule for transmitter release.