NSC 3319 Lecture Notes - Lecture 11: Tyrosine, Threonine, Phosphoprotein
10 May 2016
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Document Summary
4 categories of signal transduction: channel linked/ ligand gated examples, nach, ampa, nmda , gaba a. And ions flow across membrane: enzyme linked. Examples: mach, da, ne, 5-ht, and peptides. G-protein binds and g-protein activated: when the signal binds causes a downstream of a cascade. Types of gtp- binding proteins: monomeric, they are small g proteins. Example: ras, heterotrimeric g-proteins, prior to signal binding the receptor is in an inactive state composed of. Gdp: signal binds to receptor and one of the loops in the tmd nudges and knocks of the gdp especially at the alpha subunit. Changes in conformation causes gdp to fall of and gtp replaces. Gdp on the alpha subunit: this is an exchange, gtp binds to complex. Gtp into gdp and return everything to normal: second messengers, camp. Adenylyl cyclase: activated by g-protein coupled receptor- alpha subunit, makes camp from atp.
