NSC 3319 Lecture Notes - Lecture 10: Neurotransmitter, Metabotropic Receptor, Transition-Minimized Differential Signaling
10 May 2016
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Document Summary
Going over the categories, examples for their subunit composition, topology and structure. Ionotropic: nach-r"s - ligand gated and prototype ionotropic receptor. Subunit composition: heteropentameric (5 subunits, nmj- 2 alpha, beta, gamma, delta, alpha make up the receptor, can- 3 alpha and 2 beta, each subunit can confer different properties creating complexity in transmitter signal. Topology: each subunit has 4 hydrophobic regions that for alpha helices that cross the membrane tmd"s (transmembrane domains, each tmd2(alpha helix) of each subunit faces/ lines the central pore. Functional domains: ach binds in an extracellular pocket formed from the loops connecting the tmd"s, ach binding causes a change in protein conformational, allows i3 loop to activate a g protein which then activates some type of kinase. Example receptors: glutamate receptors, nmda- non selective but permeable to ca2+ Ligand- gated ion channel with high permeability to ca2: glycine is a co-agonist : glutamate and glycine both required to open channel.
