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Lecture

Genome Function I and II.docx

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Department
Biology
Course
BIOL 3150
Professor
Cam
Semester
Fall

Description
Genome Function I: Studying Transcriptome (Chapter 6) • Study thousands of transcripts at once o SAGE, Microarray/DNAchip, RNA-seq • SAGE – sample many mRNAto use as tags to identify transcripts • DNAchip – allow thousands of genes to be studied at once, red overexpressed, green underexpressed, yellow same o Scatterplot (red on top, yellow middle, green bottom) • Hierarchical clustering allows genes with similar patterns of expression to be grouped and compared (similar patterns function in same family) • Many mammalian genes exhibit alternative splicing, pre-mRNA can give rise to many mature mRNAs, special oligonucleotide microarrays must be designed to sense this exon skipping by depending on junctions • NGS can be used to study transcriptomes • RNA-sequencing can be used to
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